ea0073aep267 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021
Fondevila Marcos F
, Novoa Eva
, Uxía Fernández
, María J González-Rellán
, Lima Natalia
, Begoña Porteiro
, Juan Cuñarro
, Tovar Sulay
, Fidalgo Miguel
, Martinez-Chantar Maria Luz
, Sabio Guadalupe
, Marcos Miguel
, Lopez Miguel
, Dieguez Carlos
, Rubén Nogueiras
p53 family controls several metabolic and cellular functions. The p63 member regulates lipid metabolism in hepatocytes and contributes to the development of liver steatosis. Here we show that p63 plays an important role in liver fibrosis. P63 is upregulated in patients with NASH, correlating positively with fibrosis score and collagen 1a1 expression. P63 expression is also increased in different animal models of diet-induced NASH and chemically induced liver fibrosis. Mice wit...